Resumo Colletotrichum é um dos gêneros fúngicos mais importantes economicamente, afetando uma ampla gama de hospedeiros, especialmente em cultivos tropicais e subtropicais. Atualmente já existem diversos registros de infecção por micovírus em Colletotrichum spp., sendo a maioria dos já identificados classificados na família Partitiviridae. Ocorrem registros também de micovírus pertencentes à família Chrysoviridae. Compreendem vírus de genoma de (+)ssRNA e dsRNA que podem ser ou não envelopados. Ainda não foram identificados micovírus com genoma de DNA isolados de Colletotrichum. A infecção por micovírus pode ocorrer de forma latente, mas já foi observado em Colletotrichum spp. o fenômeno de hipo e hipervirulência. Além de influenciar no comportamento patogênico, a infecção pode causar mudanças fisiológicas importantes como alterações das características morfológicas, redução do crescimento vegetativo e redução na produção de conídios. O estudo com micovírus em fungos fitopatogênicos traz uma alternativa ao controle químico que é um método capaz de causar danos irreversíveis ao homem e o meio ambiente. Sob a perspectiva agrícola, os micovírus podem contribuir para agricultura sustentável como agentes de controle biológico. Isso porque obsevam-se mudanças importantes na fisiologia fúngica resultando na perda total ou redução da virulência desses patógenos.

Abstract Colletotrichum is one of the most economically important fungal genera, which affects a wide range of hosts, specifically tropical and subtropical crops. Thus far, there have been several records of mycovirus infection in Colletotrichum spp., primarily by viruses of the Partitiviridae family. There have also been records of infections by mycoviruses of the Chrysoviridae family. Mycoviruses are (+)ssRNA and dsRNA genome viruses, which may or may not be enveloped. To date, no mycovirus with a DNA genome has been isolated from Colletotrichum spp. Typically, mycoviruses cause latent infections, although hypo- and hypervirulence have also been reported in Colletotrichum spp. In addition to its effects on pathogenic behavior, mycovirus infection can lead to important physiological changes, such as altered morphological characteristics, reduced vegetative growth, and suppressed conidia production. Therefore, research on mycoviruses infecting phytopathogenic fungi can help develop alternative methods to chemical control, which can cause irreversible damage to humans and the environment. From an agricultural perspective, mycoviruses can contribute to sustainable agriculture as biological control agents via changes in fungal physiology, ultimately resulting in the total loss of or reduction in the virulence of these pathogens.

Resumo O guaranazeiro [Paullinia cupana var. sorbilis (Mart.) Ducke] é uma espécie de grande importância econômica e social no Brasil, pois é o único produtor comercial de guaraná no mundo. O método de propagação vegetativa indicado para a cultura é a estaquia que visa produtividade, tolerância e uniformidade das cultivares clonais, isso porque a reprodução por sementes possui lenta germinação e alta variabilidade genética, o que nas variedades tradicionais é um fator indesejado. Fatores genéticos podem interferir na capacidade de enraizamento da cultura. Estudos buscam alternativas que possam melhorar essa condição e potencializar o sistema produtivo. Uso de reguladores de crescimento, microrganismos promotores do crescimento vegetal, variação de substratos e adubações, tem sido estratégias utilizadas. Ensaios preliminares sobre a taxa de enraizamento caulinar e germinação de sementes com uso de fitormônio exógenos não demonstraram efeitos expressivos em relação à não aplicação desses indutores. O uso de rizobactérias, apresenta-se como atividade promissora em muitas culturas, ainda não foi demonstrado na cultura do guaraná. Por outro lado, a influência de diferentes substratos sobre o enraizamento, já demonstrou resultados significativos em função da taxa de enraizamento. A adubação das plantas matrizes conforme recomendação do sistema de produção para a cultura, comprovadamente é um procedimento eficiente. Constata-se que ainda são escassos estudos voltados à melhoria da propagação do guaranazeiro, demonstrando que novos protocolos precisam ser explorados, ou que os protocolos já utilizados sejam revistos sob outra perspectiva. Paullinia var Mart. Mart (Mart. Ducke Brasil mundo produtividade clonais genética indesejado produtivo vegetal adubações utilizadas indutores rizobactérias apresentase apresenta se culturas lado eficiente Constatase Constata explorados perspectiva (Mart

Abstract Guarana [Paullinia cupana var. sorbilis (Mart.) Ducke] is a species of great economic and social important in Brazil, as it is the only commercial guarana producer in the world. The vegetative propagation method indicated for the culture is stem cuttings, which aims at productivity, tolerance, and uniformity of clonal cultivars, because reproduction by seeds has slow germination and high genetic variability, which in traditional varieties is an undesirable factor. Genetic factors can interfere with the rooting capacity of the crop. Studies seek alternatives that can improve this condition and enhance the production system. Use of growth regulators, microorganisms that promote plant growth, variation of substrates and fertilization, have been strategies used. Preliminary tests on the rate of stem rooting and seed germination with the use of exogenous phytohormone did not demonstrate in relation to the non-application of these inducers. The use of rhizobacteria, which presents itself as a promising activity in many cultures, has not yet been demonstrated in the culture of guarana. On the other hand, the influence of different substrates on rooting has already shown consistent results as a function of rooting rate. Fertilizing the mother plants as recommended by the production system for the crop has proven to be an efficient procedure. There are still few studies aimed at improving the spread of guarana, demonstrating that new protocols need to be explored, or that the protocols already used are reviewed from another perspective. Paullinia var Mart. Mart (Mart. Ducke Brazil world cuttings productivity tolerance cultivars variability factor regulators fertilization nonapplication non application inducers rhizobacteria cultures hand procedure explored perspective (Mart

ABSTRACT Introduction/framework/objectives Psittacosis is a rare entity caused by Chlamydophila psittaci. This bacterium is transmitted through contact with contaminated birds, namely psittaciformes, which include parrots, macaws and parakeets, as pigeons and chickens. The objective of this work is to highlight the pathology and the role of Occupational Health in it. Methodology A bibliographic search was carried out on original articles published in Portuguese and English, in June 2022, in the PubMed and Cochrane Library databases, using the keywords “Psittacosis”, “Occupational exposure” and “Occupational health”. Three articles were also included, not covered by the research, relevant to the work, for reporting the Portuguese reality. Contents Outbreaks can occur in workers with occupations that involve contact with live birds or carcasses, such as veterinarians, breeders, or pet store workers. However, it is difficult to establish the precise incidence and prevalence of psittacosis, probably due to the lack of routine screening. Transmission occurs mainly by aerosols, inhalation of urine, feces or other contaminated particles; transmission between humans, although possible, is rare. The incubation period ranges from five to 14 days, but may extend to weeks in cases of subacute or latent infection. It has a clinical presentation like a flu-like syndrome and can cause disseminated and even potentially fatal disease. The most frequent findings on chest radiography are segmental or lobar consolidation, especially in the lower lobes. It can occasionally cause marked leukocytosis, c-reactive protein (CRP) is often elevated, and liver enzymes change in approximately half of hospitalized patients, with elevation of aspartate aminotransferase (AST) and low serum albumin levels. Tetracyclines are the drug of choice for treatment. Discussion and Conclusions Although the number of cases is apparently small, the impact of the disease is most likely underestimated. Thus, it is necessary to increase the awareness of this pathology both for Occupational Health professionals and for employers and workers themselves. On the other hand, an approach is needed that encompasses collaboration between human and animal health agencies, laboratories and medical and veterinary professionals, for timely surveillance, reporting and treatment. Thus, anamnesis and early recognition of the epidemiological context are extremely important, with a view to diagnosing and instituting appropriate therapy. In addition, occupational risk factors and exposure control among workers should be considered to prevent transmission in the workplace.

RESUMO Introdução/enquadramento/objetivos A psitacose é uma entidade rara, provocada pela Chlamydophila psittaci. Esta bactéria transmite-se através do contacto com aves contaminadas, nomeadamente as psittaciformes, que incluem papagaios, araras e periquitos, mas também outras espécies, como pombos e galinhas. O objetivo deste trabalho é evidenciar a patologia e o papel da Saúde Ocupacional neste contexto. Metodologia Foi realizada uma pesquisa bibliográfica de artigos publicados em português e inglês, em junho de 2022, nas bases de dados PubMed e Cochrane Library, utilizando as palavras-chave “Psittacosis”, “Occupational exposure” e “Occupational health”. Incluíram-se ainda três artigos, não abrangidos pela pesquisa, relevantes para o trabalho, por espelharem a realidade portuguesa. Conteúdo Os surtos podem ocorrer em trabalhadores com ocupações que envolvam contato com aves vivas ou carcaças, como veterinários, criadores ou trabalhadores de lojas de animais. No entanto, é difícil estabelecer a incidência e prevalência precisas da psitacose, provavelmente devido à falta de rastreios de rotina. A transmissão acontece, maioritariamente, por aerossóis, inalação de urina, fezes ou outras partículas contaminadas; a transmissão entre humanos, embora possível, é rara. O período de incubação varia de cinco a 14 dias, mas pode estender-se por semanas em casos de infeção subaguda ou latente. Tem uma apresentação clínica semelhante a uma síndrome gripal, podendo provocar doença disseminada e até potencialmente fatal. Os achados mais frequentes na radiografia do tórax são consolidação segmentar ou lobar, principalmente nos lobos inferiores. Pode ocasionalmente causar leucocitose marcada, a proteína c-reativa (PCR) encontra-se frequentemente elevada e enzimas hepáticas alteradas em aproximadamente metade dos pacientes hospitalizados, com elevação do aspartato aminotransferase (AST) e baixos níveis séricos de albumina. As tetraciclinas são o fármaco de eleição para o tratamento. Discussão e Conclusões Apesar do número de casos ser aparentemente reduzido, o impacto da doença é muito provavelmente subestimado. Assim, torna-se necessário um aumento da consciencialização desta patologia tanto para os profissionais de Saúde Ocupacional, como para os próprios empregadores e trabalhadores. Por outro lado, é necessária uma abordagem que englobe a colaboração entre agências de saúde humana e animal, laboratórios e profissionais médicos e veterinários, para vigilância, notificação e tratamento atempados. Assim, são importantíssimos a anamnese e o reconhecimento precoce do contexto epidemiológico, tendo em vista o diagnóstico e a instituição da terapêutica adequada. Associadamente, devem ser considerados os fatores de risco ocupacional e controlo das exposições entre os trabalhadores, de forma a prevenir a transmissão no local de trabalho.

Hyptis crenata, commonly known as “salva-do-Marajó”, “hortelã-do-campo”, and “hortelãzinha”, is used in folk medicine in Northeast Brazil as tea or infusion to treat inflammatory diseases. Due to the pharmacological efficacy and the low toxicity of the essential oil of Hyptis crenata (EOHc), we decided to investigate the EOHc antiedematogenic effect in experimental models of inflammation. EOHc was administrated orally at doses of 10-300 mg/kg to male Swiss albino mice. Paw edema was induced by subcutaneous injection in the right hind paw of inflammatory stimuli (carrageenan, dextran, histamine, serotonin, and bradykinin) 60 min after administration of EOHc. EOHc significantly inhibited the induced edema. The inhibitory effect of EOHc on dextran-induced edema extended throughout the experimental time. For the 30, 100, and 300 mg/kg doses of EOHc, the inhibition was of 40.28±1.70, 51.18±2.69, and 59.24±2.13%, respectively. The EOHc inhibitory effect on carrageenan-induced edema started at 10 mg/kg at the second hour (h) and was maintained throughout the observation period. At 30, 100, and 300 mg/kg doses the inhibition started earlier, from 30 min. At the edema peak of 180 min, 56, 76, and 82% inhibition was observed for 30, 100, and 300 mg/kg doses, respectively. Additionally, the effect of EOHc on carrageenan-induced paw edema was influenced by the time of administration. The EOHc also inhibited myeloperoxidase activity. In conclusion, the EOHc showed a potent effect, both preventing and reversing the edema, consistent with its anti-inflammatory use in folk medicine.

Abstract: Introduction: Heavy Menstrual Bleeding (EMB) is a frequent problem in adolescence. The prevalence of inherited bleeding disorders (IBD) as a cause of EMB is not well established and the involvement of fibri nolytic pathway defects has been poorly explored. Objective: To determine the prevalence of IBD and fibrinolysis defects in adolescents with EMBs. Patients and Method: 93 adolescents (11 to 18 years old) were included. Personal and family history of bleeding were obtained through a standard ized questionnaire. The following lab tests were performed: prothrombin time (PT), activated partial thromboplastin time (aPTT), von Willebrand factor quantification, and platelet count and function. Those patients who were not diagnosed with IBD were further evaluated with clot lysis time assay. Results: 41 patients (44%) were diagnosed as IBD (Von Willebrand disease n = 28, platelet func tion defects n=8, mild hemophilia n = 5. Decreased clot lysis time was found in 31 patients. 54% of patients diagnosed with IBD had EMB as the first hemorrhagic manifestation. Conclusion: These results support the need to evaluate the coagulation process, including the fibrinolytic pathway in the study of adolescents with EMB.

Resumen: Introducción: El Sangrado Menstrual Excesivo (SME) es un problema frecuente en la adolescencia. La prevalencia de trastornos hereditarios de la coagulación (THC) como causa del SME no está bien establecida y la participación de defectos de la vía fibrinolítica ha sido poco explorada. Objetivo: Determinar la prevalencia de THC y defectos de la fibrinólisis en adolescentes con SME. Pacientes y Método: Se incluyeron 93 adolescentes, edad 11 a 18 años. Los antecedentes personales y familiares de sangra do se obtuvieron con un cuestionario estandarizado. Se controló exámenes: tiempo de protrom- bina (TP), tiempo de tromboplastina parcial activada (TTPa), estudio del factor Von Willebrand, recuento y función plaquetaria. Los pacientes que no fueron diagnosticados como THC, se evaluaron adicionalmente con el tiempo de lisis del coágulo. Resultados: 41 pacientes (44%) fueron diagnos ticados como THC: Enfermedad de Von Willebrand n = 28, defectos de la función plaquetaria n = 8, hemofilia leve n = 5. Se confirmó disminución del tiempo de lisis del coágulo en 31 pacientes. El 54% de pacientes diagnosticado como THC, tuvo SME como la primera manifestación hemorrágica. Conclusión: Estos resultados apoyan la necesidad de evaluación de la coagulación, incluyendo la vía fibrinolítica, en el estudio de adolescentes con SME.

Resumo Fatores como o alto consumo de recursos naturais e os elevados volumes de resíduos produzidos pela indústria da construção civil alertam sobre a importância de reutilizar e reciclar os materiais. Assim, este trabalho objetivou determinar e avaliar as características físicas, químicas e mineralógicas dos finos do agregado reciclado (FAR), comparando-os com finos dos agregados naturais (FAN). Para tanto, determinaram-se a distribuição granulométrica, área específica, formato e textura superficial, índice de atividade pozolânica, óxidos presentes, teor de argamassa aderida e fases minerais. Os resultados mostraram que os FAR apresentam características que se destacam em relação aos FAN, dentre elas o formato mais irregular e superfície porosa. Entretanto, os FAR possuem melhor distribuição granulométrica, o que pode favorecer a compacidade das misturas. Em termos de desempenho pozolânico, os FAR não podem ser considerados como materiais pozolânicos, embora se faça necessário avaliá-los em finura requerida por norma.

Abstract Factors such as high consumption of natural resources and high volumes of waste produced by the construction industry warn the importance of reusing and recycling materials. Thus, this work aimed to determine and evaluate the physical, chemical and mineralogical characteristics of the fines of recycled aggregate (FRA), comparing them with fine natural aggregates (FNA). For that, particle size, specific area, shape and surface texture, pozzolanic activity index, oxides present, content of adhered mortar and mineral phases were determined. The results showed that the FRA have characteristics that stand out in relation to the FNA, among them the more irregular shape and porous surface. However, the FRA has a better particle size distribution, which may favor the compactness of the blends. In terms of pozzolanic performance, the FRA can not be considered as pozzolanic material, although it is necessary to evaluate them in the fineness required by standard.

Several groups have demonstrated that healthy individuals can present the t(14;18) translocation. In this report, the presence of the translocation was examined in healthy blood donors in Brazil, a country considered an ethnic melting pot. The translocation was detected by nested PCR in 227 peripheral blood samples from individuals with different ethnic backgrounds. The t(14;18) translocation was found in 45 of 85 White individuals (52.94%); in 57 of 72 Black individuals (79.17%); and in 68 of 70 individuals (97.14%) of Japanese-descent. In conclusion, the frequency of the t(14;18) translocation in the Brazilian population varies according to the ethnic background.

In July of 2015 and January of 2016, ticks were recovered from a Geoffroy’s cat (Leopardus geoffroyi) in Buenos Aires province and from a domestic dog (Canis lupus familiaris) in Santa Fe province, respectively. All ticks were identified as Amblyomma aureolatum. This report is the first record of A. aureolatum in Buenos Aires province and the first record in domestic dogs of Santa Fe province. Amblyomma aureolatum is a recognized vector of Rickettsia rickettsii, a spotted fever group agent in humans, and of Rangelia vitalii, a pathogenic piroplasmid of dogs, commonly referred to as "nambiuvú”. These findings allow local people to be aware of the presence of A. aureolatum to prevent infestations in dogs, and thus avoiding the occurrence of tick-borne diseases.

En los meses de julio de 2015 y enero de 2016 se colectaron garrapatas de un gato montés (Leopardus geoffroyi) localizado en la provincia de Buenos Aires y de un canino doméstico (Canis lupus familiaris) en la provincia de Santa Fe, respectivamente. El objetivo del presente trabajo es reportar el primer registro de Amblyomma aureolatum en la provincia de Buenos Aires y el primer hallazgo sobre caninos domésticos de la provincia de Santa Fe. Amblyomma aureolatum presenta importancia sanitaria ya que ha sido implicada como vector de Rickettsia rickettsii, uno de los agentes causales del grupo de las fiebres manchadas en humanos, y de Rangelia vitalii, agente causal de piroplasmosis en caninos domésticos, enfermedad vulgarmente conocida como "nambiuvú”. El presente reporte es un alerta para la comunidad sobre la presencia de A. aureolatum en nuevas localidades con el fin de implementar medidas profilácticas en caninos domésticos, para prevenir la infestación por este parásito y así evitar posibles patologías asociadas.

RESUMOEste trabalho realizou um levantamento sobre o uso de plantas medicinais na cidade de Picos-PI, identificou as plantas cultivadas no horto pertencente ao Laboratório Fitoterápico de Picos (LAFIPI), e analisou o uso de fitoterápicos dispensados pelo Programa Farmácia Viva no triênio 2008-2010. Do total dos 750 entrevistados, 37,6% foram homens e 62,4 % mulheres, dentre os quais a maioria não concluiu o segundo grau (69,2%) e 77,2% possuíam renda mensal de até dois salários mínimos. Com relação ao consumo de plantas medicinais, 76,3% afirmaram utilizá-las para tratar doenças, principalmente por considerá-las mais saudáveis (84,8%). A indicação do uso foi orientada, sobretudo, por familiares (82,2%), embora a maioria adquira as plantas em feiras livres (32,8%). Das 127 plantas relatadas, as mais citadas foram erva-cidreira, boldo e hortelã, sendo as folhas a parte mais utilizada (42,3%), predominantemente por infusão (39,4%). As aplicações mais lembradas foram para tratar dores em geral (17%), distúrbios respiratórios (16,5%) e digestivos (16%). As espécies mais cultivadas no horto são chambá (Justicia pectoralis), alecrim pimenta (Lippia sidoides), malva santa (Plectranthus barbatus) e erva cidreira (Lippia alba). O lambedor de chambá foi o fitoterápico mais procurado pela população entre 2008 e 2010. Esse estudo descreveu, pela primeira vez, o uso tradicional de plantas medicinais no município de Picos e demonstrou, também de forma inédita, a relevância de investimentos do Programa Farmácia Viva no município de Picos e sua inclusão no Programa Saúde da Família como forma de disponibilizar à população de baixa renda fitoterápicos produzidos localmente a custos reduzidos.

ABSTRACTThis study performed a research about the use of medicinal plants in Picos city, identifying the plants grown in the garden belonging to the Laboratory of Phytotherapics in Picos (LAFIPI) and analying the use of phytotherapics distributed by the Farmácia Viva Project between 2008-2010. From the total of 750 interviewed participants, 37.6% were men and 62.4 % women. Most of them do not have secondary education (69.2%) and 77.2% had an income of up until two minimum wages. Regarding consumption of medicinal plants, 76.3 % used them to treat diseases, mainly because they considered them to be healthier (84.8%). The indication of use of the plants was mainly suggested by relatives (82.2%), even though the majority of the participants acquires plants in open markets (32.8%). From the 127 plants mentioned, the most cited ones were balm, boldo and mint, and leaves were the most utilized parts (42.3%), predominantly by infusion (39.4%). The most common reasons for the usewere to treat pain in general (17%), and respiratory (16.5%) and digestive disorders (16%). The most cultivated species in the garden were chambá (Justicia pectoralis), alecrim pimenta (Lippia sidoides), malva santa (Plectranthus barbatus) and erva cidreira (Lippia alba). The "chambá licker" was the most herbal medicine searched by the population between 2008 and 2010. This investigation described, for the first time, the traditional use of medicinal plants in Picos and demonstrated,alsounprecedentedly, the relevance of investments in the Farmácia Viva Project in Picos city and its inclusion in the Family Health Program as a strategyin order to provide locally producedphytotherapics for low-income population at low costs.

Resumo Larvas de terceiro estágio (L3) de Hysterothylacium sp. foram coletadas pela primeira vez em juvenis de pirarucu Arapaima gigas cultivados no Rio Preto da Eva, Estado do Amazonas. Noventa e oito (98) dos 100 peixes examinados estavam parasitados. Quinhentos e noventa larvas de Hysterothylaciumsp.foram coletados no intestino, estômago e cecos pilóricos. O índice parasitário de intensidade média foi de 6,02 (±5,75) variando de 1 a 40 larvas por hospedeiro e o de abundância média foi de 5,9 (±5,76). A. Gigas é um novo registro de hospedeiro para larvas de Hysterothylacium sp. no Brasil, também sendo, o primeiro registro de larvas de Hysterothylacium sp. com potencial zoonótico em pirarucu da América do Sul.

Abstract Third-stage larvae (L3) of Hysterothylacium sp. were collected by the first time in juveniles of pirarucu Arapaima gigas farmed in the Rio Preto da Eva, Amazonas state. Ninety-eight (98) out of 100 examined fish showed to be parasitized. Five hundred and ninety larvae of Hysterothylacium sp. were collected from the intestines, stomach and pyloric caeca. The mean intensity of parasite indexes was 6.02 (±5.75) ranging from 1 to 40 larvae per host and the mean abundance was 5.9 (±5.76). The A. gigas is the new host record for larvae of Hysterothylacium sp. in Brazil, and this is the first record of larvae of Hysterothylacium (Nematoda: Anisakidae) with zoonotic potential in the pirarucu from South America.

We measured circulating endothelial precursor cells (EPCs), activated circulating endothelial cells (aCECs), and mature circulating endothelial cells (mCECs) using four-color multiparametric flow cytometry in the peripheral blood of 84 chronic myeloid leukemia (CML) patients and 65 healthy controls; and vascular endothelial growth factor (VEGF) by quantitative real-time PCR in 50 CML patients and 32 healthy controls. Because of an increase in mCECs, the median percentage of CECs in CML blast crisis (0.0146%) was significantly higher than in healthy subjects (0.0059%, P<0.01) and in the accelerated phase (0.0059%, P=0.01). There were no significant differences in the percentages of CECs in chronic- or active-phase patients and healthy subjects (P>0.05). In addition, VEGF gene expression was significantly higher in all phases of CML: 0.245 in blast crisis, 0.320 in the active phase, and 0.330 in chronic phase patients than it was in healthy subjects (0.145). In conclusion, CML in blast crisis had increased levels of CECs and VEGF gene expression, which may serve as markers of disease progression and may become targets for the management of CML.

Para materiais frágeis, nos quais algumas propriedades podem ser representadas pela distribuição de Weibull, destaca-se a necessidade de que um método seja apresentado para a determinação de lotes mínimos. Um modelo foi construído a partir de um método já aplicado para distribuição normal, com o auxílio de ferramentas estatísticas, desenvolvida em metodologia quantitativa e exploratória. Realizada a coleta números verdadeiramente aleatórios, em distribuição normal, conforme coeficientes de variação pré-estabelecidos para quatro faixas de numéricas, simulando também uma dispersão aleatória. Estes números foram desdobrados em distribuições menores, simulando tamanho de lotes. Utilizou-se a metodologia de Cochran, com a adoção de critérios específicos para a distribuição de Weibull. Foram produzidas tabelas numéricas que relacionam os coeficientes de variação de Weibull, faixa numérica e parâmetros de Weibull para a determinação de lotes mínimos em função do número máximo de amostras.

Regarding brittle materials, where some properties can be represented by Weibull distribution, the necessity of a new method of minimum sample be presented must be highlighted. Thus, a model has been built as baseline from a method already applied to normal distribution supported by statistical tools. Applying Cochran methodology, a new model was built, starting from numbers truly random, under normal distribution and using variation coefficients by four given numerical ranges faking the brittle materials randomly dispersion. Such numbers packs were deployed into new smaller distributions. Ensuring normal and distribution compliance. Adopting specific criteria, numerical tables are outcome, which encloses coefficient of variation, numerical ranges and Weibull parameters with minimum batch number as a function of the maximum number of batches.

Quantitative seismology is an important tool for investigating mine-induced seismicity and the quantification of the seismic rock mass response. The spatio-temporal interpretation of seismic data within an ever-changing three-dimensional mining environment provides some challenges to the interpretation of the rock mass response. A grid-based approach for the interpretation of spatial variation of the rock mass response provides some benefits compared with approaches based on spatial filters. This paper discusses a grid-based interpretation of seismic data. The basic methods employed in the evaluation of the parameter values through space are discussed and examples of applications to different mine sites given.

Objective: To report the data of the Home Parenteral Nutrition (HPN) registry of the NADYA-SENPE working group for the years 2011 and 2012. Methodology: We compiled the data from the on-line registry introduced by reviewers of NADYA group responsible for monitoring of NPD introduced by since January 1, 2011 to december 31, 2012. Included fields were: age, sex, diagnosis and reason for HPN, access path, complications, beginning and end dates, complementary oral or enteral nutrition, activity level, autonomy degree, product and fungible material supply, withdrawal reason and intestinal transplant indication. Results: Year 2010: 184 patients from 29 hospitals, representing a rate of 3.98 patients/million inhabitants/ year 2011, with 186 episodes were recorded NPD. During 2012, 203 patients from 29 hospitals, representing a rate of 4.39 patients/million inhabitants/year 2012, a total of 211 episodes were recorded NPD . Conclusions: We observe an increase in registered patients with respect to previous years.Neoplasia remains as the main pathology since 2003. Although NADYA is consolidated registry and has been indispensable source of information relevant to the understanding of the progress of Home Artificial Nutrition in our country, there is ample room for improvement. Especially that refers to the registration of pediatric patients and the registration of complications.

Objetivo: Comunicar los datos del registro de Nutrición Parenteral Domiciliaria (NPD) del grupo de trabajo NADYA-SENPE de los años 2011 y 2012. Material y métodos: Recopilación de los datos del registro "on-line" introducidos por los colaboradores del grupo NADYA responsables del seguimiento de la NPD desde el 1 de enero de 2011 al 31 de diciembre de 2012 dividido por años naturales. Resultados: Año 2010: Se registraron 184 pacientes, procedentes de 29 hospitales, lo que representa una tasa de 3,98 pacientes/millón habitantes/año 2011, con 186 episodios de NPD. Durante el año 2012 se registraron 203 pacientes, procedentes de 29 hospitales, lo que representa una tasa de 4,39 pacientes/millón habitantes/año 2012, con un total de 211 episodios de NPD. Conclusiones: Se observa un aumento progresivo de los pacientes registrados respecto a años anteriores. El principal grupo patológico sigue siendo oncológico ocupando el primer lugar desde 2003. Aunque el registro NADYA es un registro consolidado y ha sido y es fuente imprescindible de información relevante para el conocimiento de los avances de la Nutrición Artificial Domiciliaria en nuestro país, queda un amplio margen para la mejora. En especial lo que hace referencia al registro de pacientes pediátricos y al registro de las complicaciones.

The perovskite BaPb0.9Sb0.1O3 was prepared through the ceramic route and, after being chemical, structural and electrochemically characterized, it was used in the electrochemical oxidation of guaiacol, using Na2SO4 as electrolyte, at current densities of 5 and 10 mA cm-2 and initial guaiacol concentrations of 50, 100 and 200 mg L-1 . The guaiacol degradation was followed by UV-Visible absorbance measurements, Chemical Oxygen Demand (COD) tests and Dissolved Organic Carbon (DOC) analysis. The combustion efficiency was also determined. Results have shown COD removals between 40 and 85 % and DOC removals from 34 to 66 % after 120 h assays. The absolute COD and DOC removals increase with guaiacol initial concentration and applied current density. The mineralization tendency, measured as the combustion efficiency, was maximum for the applied current density of 10 mA cm-2 and a guaiacol initial concentration of 200 mg L-1.